James Taylor will captain England for the first time in the one-day international against Ireland on 8 May.
Nottinghamshire batsman Taylor, 25, stands-in for regular captain Eoin Morgan, who is playing for Sunrisers Hyderabad in the Indian Premier League.
Yorkshire bowler Tim Bresnan is recalled, with six potential ODI debutants in an initial 11-man party.
More players will be added following selection for the third Test against West Indies on Friday.
One man on the tour of the Caribbean definitely included is wicketkeeper Jonny Bairstow, but the likes of James Anderson, Stuart Broad, Joe Root, Ian Bell and Moeen Ali are set to be rested.
Hampshire batsman James Vince, Kent wicketkeeper-batsman Sam Billings, Somerset all-rounder Lewis Gregory, Northants all-rounder David Willey and Surrey pair Zafar Ansari and Jason Roy, a spin-bowling all-rounder and opening batsman respectively, could all make their ODI debuts.
The one-off game is England’s first limited-overs match since being eliminated at the group stage of the World Cup in New Zealand and Australia.
“We are expecting a very competitive match against a talented Ireland side and this fixture gives us a great opportunity to look at players who have performed well in county cricket and for the Lions,” said national selector James Whitaker.
“We are starting to identify players we believe can make a real impact in limited-overs cricket in the next four years as we build towards the World Cup in 2019.”
Taylor, who made his debut in the same fixture four years ago, was recalled to the England team on their tour of Sri Lanka in December and has played in all of their ODIs since.
In 17 matches, he has made 492 runs at an average of 35.14, with a highest score of 98 not out, made against Australia in England’s opening match of the World Cup.
“To be given the opportunity to lead your country is a huge honour,” said Taylor. “It’s going to be brilliant leading an England team in a one-day international.
“We know it will be a tough game against Ireland and this match provides a great chance for us all to show we can play a huge role in limited-overs cricket in years to come.”
Ireland recalled bowler Tim Murtagh to their squad for the match at Malahide Cricket Club near Dublin, where captain William Porterfield is set to make his 200th international appearance.
Initial England squad to play Ireland: James Taylor (capt) Zafar Ansari, Jonny Bairstow (wkt), Sam Billings (wkt), Tim Bresnan, Steven Finn, Lewis Gregory, Alex Hales, Jason Roy, James Vince, David Willey.
