Owen Farrell will start at fly-half for England in Saturday’s first Test against Australia in Brisbane with George Ford dropping to the bench.
Luther Burrell replaces Farrell at inside centre, while Marland Yarde is picked on the wing ahead of Jack Nowell, who is named as a replacement.
Ex-captain Chris Robshaw is back on the blind-side after missing the Wales win.
Coach Eddie Jones has opted to start with the same pack which began the final Six Nations game against France.
England secured the Grand Slam with a 31-21 victory over Les Bleus in Paris, but they have never won a Test series in Australia – winning just three of their 17 Tests down under.
Jones said: “We have picked a side to win in Brisbane. It’s important we get off to a positive start and we’ll arrive ready to play physical and aggressive rugby.”
Australia have named three debutants – centre Samu Kerevi, lock Rory Arnold and winger Dane Haylett-Petty – as they bulk up their side for the first Test.
England fly-half Ford, 23, missed six out of seven kicks at goal during the 27-13 warm-up victory over Wales and that, combined with Farrell’s brilliant form for title-winning Saracens, seems to have influenced Jones’ decision.
There had been suggestions Maro Itoje might move from lock to blind-side flanker in place of Robshaw, who missed the Wales game to attend his brother’s wedding, with Joe Launchbury coming into the second row.
However, Wasps lock Launchbury – man of the match against Wales – has to settle for a place on the bench alongside Northampton second row Courtney Lawes.
Alex Goode, the newly-crowned Aviva Premiership player of the season, has been left out of the 23, while full-back Mike Brown is poised to win his 50th cap.
Jones said the series was an opportunity for his youthful side to “create history”.
“If you look at England’s record in Australia it’s pretty ordinary – we’ve only ever won three games in Australia,” he added.
“The Wallabies are ranked second in the world and have the World Rugby coach of the year, so that’s why they start as favourites.
“We have a young squad with an average age of 24 so we are still developing and improving. It’ll be a great challenge for us and one we’re looking forward to meeting head on.”
England team to play Australia: 15. Mike Brown; 14. Anthony Watson, 13. Jonathan Joseph, 12. Luther Burrell, 11. Marland Yarde; 10. Owen Farrell, 9. Ben Youngs; 1. Mako Vunipola, 2. Dylan Hartley, 3. Dan Cole, 4. Maro Itoje, 5. George Kruis, 6. Chris Robshaw, 7. James Haskell, 8. Billy Vunipola
Replacements: 16. Luke Cowan-Dickie, 17. Matt Mullan, 18. Paul Hill, 19. Joe Launchbury, 20. Courtney Lawes, 21. Danny Care, 22. George Ford, 23. Jack Nowell
